AOD-9604
Overview
AOD-9604, or Anti-Obesity Drug-9604, is a synthetic peptide developed initially for its potential in the treatment of obesity. It is a modified form of the human growth hormone (hGH) fragment encompassing amino acids 176-191 at the C-terminus of the hormone. This peptide was designed to mimic the fat-burning properties of hGH without its muscle-building effects or other hGH-associated side effects.
The development of AOD-9604 stems from research into the lipolytic (fat-burning) effects of hGH. Scientists discovered that a specific region of the growth hormone molecule is responsible for its fat-reducing properties. AOD-9604 was created by isolating and modifying this fragment to maximize its potential for weight loss and fat metabolism.
In terms of mechanism, AOD-9604 stimulates lipolysis – the breakdown of fats and lipids – and inhibits lipogenesis, the transformation of non-fat food materials into body fat. Unlike hGH, AOD-9604 does not have an impact on growth or insulin resistance. It is believed to mimic the way natural growth hormone regulates fat metabolism but without the adverse effects on blood sugar or growth that is seen with unmodified hGH.
Clinical trials of AOD-9604 have shown mixed results in terms of its efficacy in obesity treatment. While some studies have indicated potential benefits in terms of fat reduction and weight loss, others have not found significant effects. As a result, AOD-9604 has not received approval from regulatory bodies like the FDA for the treatment of obesity.
In comparison to other weight-loss drugs like Semaglutide and Tirzepatide, which influence appetite and insulin secretion, AOD-9604's action is more focused on fat metabolism. However, its clinical utility is still under investigation, and it remains a research chemical rather than a widely accepted pharmaceutical treatment for obesity.
Its use has also been explored in the context of bodybuilding and athletic performance, primarily for its purported fat-burning properties, though such uses are not supported by clinical studies and are not recognized by regulatory health authorities.
Dosage
To calculate the dosage for AOD-9604 at 300 mcg per day from a 5 mg vial reconstituted with 2 mL of bacteriostatic water, follow these steps:
1. Concentration Calculation:
- You have 5 mg (or 5000 mcg, since 1 mg = 1000 mcg) of AOD-9604.
- You add 2 mL of bacteriostatic water.
- The concentration is 5000 mcg / 2 mL = 2500 mcg/mL.
2. Daily Dose Calculation:
- The desired daily dose is 300 mcg.
- To find out how much volume contains 300 mcg, divide the dose by the concentration: 300 mcg / 2500 mcg/mL = 0.12 mL.
3. Syringe Measurement:
- If using a 0.5 mL syringe marked in 50 units, each unit is equal to 0.01 mL (since 0.5 mL = 50 units).
- So, for 0.12 mL: 0.12 mL / 0.01 mL/unit = 12 units.
Therefore, for a daily dose of 300 mcg of AOD-9604 from your prepared solution, you would draw up to the 12-unit mark on a 0.5 mL, 50-unit insulin syringe.
Remember, this calculation is for informational purposes only. Actual medication dosing should always be done under the supervision of a healthcare professional.
AOD-9604, since it is related to growth hormone pathways should be taken once daily on an empty stomach.
Buy AOD-9604 from Sigma Compounds.
Risks
AOD-9604, being a modified fragment of human growth hormone (hGH), was initially developed to harness the fat-burning properties of hGH without its muscle-building effects or other associated side effects. However, as with any peptide or drug, there are potential risks and side effects to consider:
1. Lack of Long-Term Studies: One of the primary concerns with AOD-9604 is the lack of comprehensive long-term clinical studies to thoroughly assess its safety profile.
2. Efficacy Concerns: Clinical trials have shown mixed results regarding its effectiveness in obesity treatment. This inconsistency raises questions about its overall efficacy.
3. Potential Immune Response: As a synthetic peptide, there is a possibility that AOD-9604 could elicit an immune response, although this risk is generally considered low.
4. Injection Site Reactions: Common with many injectable drugs, these can include redness, soreness, and swelling at the injection site.
5. Unknown Side Effects: Given the limited data on AOD-9604, there may be side effects that are not yet fully understood or documented.
6. Regulatory Status: AOD-9604 is not approved by major regulatory bodies like the FDA for any medical use. This means it hasn't passed the stringent testing that approved drugs undergo to ensure their safety and effectiveness.
7. Off-Label Use Risks: Usage in bodybuilding or athletic enhancement contexts is not supported by clinical evidence and falls outside of approved medical guidelines, carrying unknown risks.
8. Interactions with Other Medications: The potential interactions of AOD-9604 with other medications or supplements have not been thoroughly studied.
It's important to approach AOD-9604 with caution, and it should ideally be used under the guidance of a healthcare professional. Given the uncertainties surrounding its effects and safety profile, thorough consultation and consideration are advised before its use.
It's important to note that this is not an exhaustive list, and patients should be aware of other potential side effects. Anyone considering or currently taking AOD-9604 should discuss potential risks and benefits with their healthcare provider. Additionally, any unusual or severe symptoms should be reported to a healthcare professional immediately.